Polynucleotides are one of the fastest-growing injectable categories in aesthetic medicine. This section brings together professional polynucleotide (PN) and PDRN products for clinics and practitioners: Plinest, Plinest Eye, Plinest One and Newest One by Mastelli (Italy), and the TwAc PDRN boosters by Yuma Medical (UK). All products are original, with prices in GBP or EUR and delivery to the UK and across Europe.
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Polynucleotides (PN & PDRN)
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What are polynucleotides and PDRN?
Polynucleotides are chains of nucleotides, the building blocks of DNA, purified from fish DNA. In the skin they stimulate fibroblasts and support cell renewal, microcirculation and collagen production. That is why a polynucleotide treatment works on skin quality, not on volume.
PN and PDRN both come from salmon DNA and differ in how the DNA is fragmented and purified. Mastelli uses its own PN-HPT® technology (Polynucleotides Highly Purified Technology). The PDRN (polydeoxyribonucleotide) in TwAc has a molecular weight of at least 1,480 kDa and is purified in France by HTL Biotechnology. Products also differ in concentration, volume and whether hyaluronic acid is added, so the choice depends on the area and the skin problem.
Polynucleotides vs skin boosters and dermal fillers
Dermal fillers add volume and shape, polynucleotides do not. Classic skin boosters are based on hyaluronic acid and mainly hydrate. Polynucleotides target regeneration: thin, tired or scarred skin, crepey skin under the eyes, stretch marks and laxity.
In practice the two are often combined. TwAc 2.0 and TwAc 3.0 already pair PDRN with hyaluronic acid in one syringe, and Newest One combines PN-HPT® polynucleotides with non-cross-linked hyaluronic acid for body skin. When the patient needs volume, look at dermal fillers instead.
Our polynucleotide range
- Plinest — PN-HPT® 20 mg/ml, 1 × 2 ml syringe. Face, neck and décolleté: fine lines, loss of tone, scars, post-acne, enlarged pores.
- Plinest Eye — PN-HPT® 7.5 mg/ml, 1 × 2 ml. The thin skin around the eyes: dark circles, puffiness, fine lines.
- Plinest One — PN-HPT® 2 mg/ml without hyaluronic acid, 5 vials × 4 ml. Large areas of the face and body: laxity, dryness, stretch marks, scars.
- Newest One — PN-HPT® 1–2 mg/ml, non-cross-linked hyaluronic acid 1 mg/ml and mannitol, 5 vials × 4 ml. Hydration and renewal of body skin.
- TwAc 2.0 — PDRN 7.5 mg/ml + hyaluronic acid 12 mg/ml, 1 × 3 ml, no lidocaine. Dehydration, fine wrinkles, uneven tone.
- TwAc 3.0 — PDRN 20 mg/ml + hyaluronic acid 20 mg/ml, 1 × 3 ml. Deep wrinkles, laxity, loss of skin density.
- TwAc Eyes — PDRN 10 mg/ml, 1 × 1 ml. Under-eye area, dark circles, crow’s feet.
How polynucleotide treatments are carried out
All polynucleotides in this section are injected into the dermis by a qualified practitioner, following the manufacturer’s instructions. Plinest and Plinest Eye are given with micro-droplet or retrograde linear technique, usually 3–4 sessions every 14–21 days. A TwAc 2.0 course is 2 sessions 14 days apart, TwAc 3.0 is 2 sessions 21 days apart, and TwAc Eyes is 3 sessions 7 days apart.
Because PN and PDRN come from fish DNA, patients with a known fish allergy are not treated. The exact protocol, depth and needle are always chosen by the practitioner.
Buying polynucleotides in the UK and Europe
PriorMedical supplies polynucleotides to licensed aesthetic professionals only. To place an order, create a professional account. UK visitors see prices in GBP, EU visitors in EUR. Delivery to the UK takes 2–5 days by DHL with tracking, and the shipping cost is calculated at checkout. When you order several units of one product, volume discounts apply automatically in the cart.
Frequently asked questions about polynucleotides
What are polynucleotides?
Polynucleotides are purified DNA fragments, usually from salmon, used in injectable treatments to regenerate the skin. They stimulate fibroblasts and support collagen production, microcirculation and hydration.
What is the difference between PN and PDRN?
PN and PDRN are both polynucleotides from salmon DNA, made with different purification and fragmentation processes. In this section, PN is represented by Mastelli’s PN-HPT® (Plinest, Newest) and PDRN by the TwAc boosters from Yuma Medical.
How are polynucleotides different from skin boosters?
Polynucleotides regenerate the skin, while hyaluronic acid skin boosters mainly hydrate it. Some products combine both: TwAc 2.0, TwAc 3.0 and Newest One contain polynucleotides together with hyaluronic acid.
How many polynucleotide sessions are needed?
A typical course is 2–4 sessions, depending on the product. Plinest is usually 3–4 sessions every 14–21 days, TwAc 2.0 is 2 sessions 14 days apart, and TwAc Eyes is 3 sessions 7 days apart; the practitioner sets the final plan.
Who can buy polynucleotides from PriorMedical?
Only licensed aesthetic professionals: doctors, nurses and clinics. Orders are placed through a professional account on the site.
Where can I buy polynucleotides in the UK?
You can buy Plinest, Newest and TwAc polynucleotides online at PriorMedical with a professional account. Prices are shown in GBP, and delivery to the UK takes 2–5 days.